血清急性时相反应蛋白的测定在肺炎患者中的临床意义

目的探讨血清中补体C3和C4、C反应蛋白(CRP)、前白蛋白(PA)等急性时相反应蛋白检测对严重急性肺炎的诊断价值。方法透射比浊法检测74例临床诊断的肺炎患者和30名健康体检者血清中C3、C4、CRP和PA的含量。结果对照组C3为(1.21±0.51)g/L,C4为(0.38±0.26)g/L,CRP为(0.42±0.26)mg/L,PA为(376士74.08)mg/L;肺炎组C3为(1.30±0.46)g/L,C4为(0.64±0.27)g/L,CRP为(0.95±0.52)mg/L,PA为(160.9±76.48)mg/L。肺炎患者PA明显降低,C4和CRP则明显升高,差异有显著性;各组C3含量比较差异无显著性。结论检测急性时相蛋白CA、CRP和PA有助于急性肺炎的早期鉴别诊断。

Determination of serum acute phase reaction protein in patients with pneumonia

【Objective】To study the diagnostic value of determinations of serum acute phase reactionprotein,such as complement 3（C3）,complement 4（C4）,prealbumin（PA） and C-reative protein（CRP）,etc,in patients with pneumonia.【Methods】Serum levels of C3,C4,PA and CRP were determined by turbidimetry in 74 of other pneumonia and 30 normal persons.【Results】Serum concentrations of C3,C4,CRP and PA were（1.21 ± 0.51） g/L,（0.38 ± 0.26） g/L,（0.42 ± 0.26） mg/L and（376 ± 74.08） mg/L in noraml persons,respectively.Serum level of PA was significantly lower and levels of C4 and CRP significandy in patients with SARS higher than those in patients with other pneumonia and normal persons（P〈0.01）.There wasno significant difference in serum level of C3 between the three groups（P〉0.05）.【Conclusions】Determination of serum level of C4.CRP and PA in suspected patients is beneficial to early differentialdiagnosis for pneumonia.