TIG2在寻常型银屑病中的表达变化及意义

目的 研究TIG2在寻常型银屑病中的作用机制.方法 用免疫组化和原位杂交的方法检测正常组织,未受累组织和银屑病皮损中TIG2蛋白和mRNA的表达变化.结果 在正常组织及未受累组织中,TIG2表达于表皮全层,在银屑病周围皮损中,可见TIG2阳性染色于棘层上部,在棘层下部及基底层中表达较少,而在银屑病中间皮损中无表达.TIG2在正常和未受累皮肤基底层中的表达高于其在银屑病边缘皮损基底层中的表达(p<0.01);TIG2在正常皮肤和未受累皮肤中的表达高于其在银屑病中间皮损中的表达(P<0.01);银屑病边缘皮损基底上层中的表达高于其在银屑病中间皮损中的表达(P<0.01).结论 TIG2可保持表皮正常分化功能,TIG2的降低可能参与银屑病的发生和发展.

Alteration of tazarotene induced gene-2 expression in psoriasis vulgaris

Objective To investigate the role of tazarotene induced gene-2(TIG2) in psoriasis vulgaris.Methods TIG2 protein and mRNA expressions in normal tissues, psoriatic lesions and uninvolved skin tissues were detected by immunohistochemistry and in situ hybridization, respectively.Results TIG2 protein and mRNA were expressed in all the layers of normal and uninvolved epidermis.TIG2 expression was detected in the upper layers of the stratum spinosum of the marginal region of the psoriatic lesions, but not in the c...