2011年湖北省麻城市健康人群百日咳、白喉、破伤风抗体水平调查

目的调查评估麻城市2011年健康人群中百日咳、白喉和破伤风抗体水平。方法随机抽取健康人群血清480人份，分为六个年龄组，采用ELISA法检测百日咳IgG、白喉IgC和破伤风IgG。结果百日咳IgG、白喉IgG和破伤风IgG保护率分别为21．04％、73．33％和67．71％。3-6岁与7-14岁白喉抗体保护率分别为90％和76．67％，两年龄段抗体保护率差异有统计学意义（X^2=29．73，P〈0．01）；3-6岁与7-14岁破伤风抗体保护率分别为93．33％和66．67％，两年龄段抗体保护率差异有统计学意义（X^2=40．52，P〈0．01）。结论麻城市人群中百日咳抗体水平较低，6岁以后人群中白破抗体水平下降明显。

Investigation on Antibody Levels Against Pertussis, Diphtheria and Tetanus Among Healthy Population of Macheng City in Hubei Province in 2011

Objective To survey and evaluate the antibodies levels against pertussis, diphtheria and tetanus among healthy population of Macheng City in Hubei Province in 2011. Method ELISA was used to detect serum levels of IgG against pertussis, diphtheria and tetanus in 480 healthy individuals who were divided into six age groups. Results The anti- body protection rates of pertussis, diphtheria and tetanus were 21.04 %, 73.33 % and 67.71%, respectively. The antibody pro- tection rates of diphtheria in children aged 3 - 6 years and 7 - 14 years were 90% and 76.67% respectively, and there were sta- tistically significant differences between the two age groups （X^2 = 29.73, P 〈 0.01 ）. The antibody protection rates of tetanus in children aged 3- 6 years and 7- 14 years were 93.33% and 66.67% respectively, and the differences were statistically signifi- cant between the two age groups （X^2 = 40.52, P〈0.01 ）. Conclusions The antibody level of pertussis in healthy population of Macheng City is lower; moreover, the antibody levels of diphtheria and tetanus decrease significantly among the population aged over 6 years.