非小细胞肺癌患者血清中TSGF及CA125水平检测的意义

目的探讨恶性肿瘤特异性生长因子(TSGF)和糖类抗原-125(CA125)血清水平检测对非小细胞肺癌(NSCLC)患者诊断的临床价值。方法选取50例NSCLC患者,及50例良性肺部病变患者,检测血清TSGF和CA125水平,比较不同组别患者及肺癌患者不同病理类型、不同临床分期血清TSGF和CA125的表达水平。结果血清TS-GF和CA125水平在肺癌组明显高于肺良性病变组(P<0.001);肺癌患者CA125表达水平与组织类型有关,肺腺癌明显高于肺鳞癌(P<0.01);肺癌患者血清TSGF和CA125的阳性率与NSCLC临床分期有关,临床分期越晚,其阳性率越高。结论 CA125及TSGF均对肺癌的辅助诊断具有一定价值,临床上需要结合症状、影像学及病理学综合判断,为NSCLC提供更好的诊疗效果。

Significance of Serum TSGF and CA125 Detection for the Patients with Non-small Cell Lung Cancer

Objective To explore the clinical values of serum tumor specific growth factor （TSGF） and carbohydrate anti- gen （CA125） detection in the diagnosis of non- small cell ltm~ cancer （NSCLC）. Methods The serum TSGF and CA125 levels were measured in 50 patients with NSCLC and 50 cases with benign lung diseases. The detection results were compared be- tween the two groups and among patients with lung cancers of different pathological types and clinical stages. Resdts The se- rum TSGF and CA125 levels in the lung cancer group were significantly higher than those in the control group （P 〈 0. 001 ）. The serum CA125 level was related with the pathological types of the lung carcinoma, which was statistically higher in the patients with lung adenocarcinoma than in those with lung squamous cell carcinoma （ P 〈 0.01 ）. The positive rates of serum TSC-F and CA125 in patients with NSCLC were related with the clinical stage of the caxcinoma. The later the clinical stage, the higher the positive rates. Conclusions Serum TSGF and CA125 detection is of clinical significance in the diagnosis of patients with non -small cell lung cancer.