2009-2010年长沙市艾滋病抗病毒治疗效果分析

目的评价目前高效抗逆转录病毒治疗(HAART)方案的疗效,为深入规范开展抗病毒工作提供依据。方法从《艾滋病网络直报信息系统》中下载2009年1月1日-2010年12月31日的抗病毒治疗数据库的历史卡片,采用Excel2003和SPSS13.0对抗病毒治疗数据库中接受免费抗病毒治疗基本情况表及随访表内容进行分析。结果治疗前,病例的CD4+T淋巴细胞计数均值为(142.33±112.71)个/μl,治疗12个月,治疗病例CD4+T淋巴细胞计数呈明显上升趋势,均值为(308.23±162.58)个/μl,治疗3、6、9和12个月与治疗前CD4+检测结果相比,其差异有统计学意义(P<0.05)。治疗满6个月后,有128例进行了病毒载量检测,其中82.0%的病例病毒载量计数下降到检测不到水平。结论长沙市艾滋病例在接受抗病毒治疗1年后,治疗效果明显,病例状态持续稳定。

Analysis on Therapeutic Effect of Highly Active Antiretroviral Therapy on AIDS in Changsha City from 2009 to 2010

Objective To evaluate the efficacy of highly active antiretroviral therapy （HARRT）, and to provide a basis for promoting HARRT work. Methods The data were downloaded from history cards of antiretroviral therapy （ART） data- base of AIDS Direct Reporting Network System from January 1, 2009 to December 31, 2010. Basic information tables of free ART and follow- up cards were analyzed with EXCEL 2003 and SPSS 13.0 software. Results Before the treatment, the mean CD4＋ T lymphocyte count was 142.33 ± 112.71/μl. After 12 months of treatment, the mean CD4＋ T lymphocyte count reached 308.23 ± 162.58/μl. There were statistically significant differences in the detection results of CD4＋ T lymphocyte count between the pre - treatment and the post - treatment for 3, 6, 9, and 12 months （P 〈 0.05）. After 6 months of treatment, 128 cases received viral load test, 82.0 % of their results were below the detection limit. Conclusions After one year of treat- ment, the therapeutic effect of HARRT on AIDS is obvious in Chan~sha, and the situation of the cases remains stable.