阿尔茨海默病的免疫治疗研究新进展

Alzheimer's disease(AD) is the most common cause of dementia. Based on the amyloid cascade hypothesis, vaccine therapy for AD was developed as a curative treatmant. Although the clinical trials of active vaccination for AD patients were halted due to the development of meningoencephalitis in some patients, analy-sis of the clinical and pathological findings of treated patients, shaved that vaccine therapy was effective. To a-void the possible meningoencephalitis resulting from Aβ vaccination, various strategies have been attempted in-cluding developing shorter immunogens, using new adjuvant, modifying adminiatin ways, developing non-viral DNA vaccine, and using catalytic antibodies to Aβ. Experimental studies in transgenic mouse models of AD have demonstrated that the strategies mentioned above are safe and effective for the treatment of AD.

New advances in immunotherapy for Alzheimer's disease