7例真菌性败血症的临床分析

目的 探讨医院内真菌性败血症的临床特点与治疗方法.方法 对1999-2009年7例真菌败血症患者进行回顾性临床分析.结果 7例中,易感危险肉素以严重基础疾病(100.0%)、使用广谱抗菌药物(86.0%)、应用糖皮质激素(57.0%)最为突出;主要病原菌为假丝酵母菌属包括白色假丝酵母菌和非白色假丝酵母菌(热带假丝酵母菌、克柔假丝酵母菌);病死率为86.0%.结论 败血症多发生在机体免疫功能降低的患者中,主要病原菌为白色假丝酵母菌和非白色假丝酵母菌,应早期开展经验性治疗,目前临床应用氟康唑抗真菌治疗剂量偏小.

Clinical Analysis of 7 Patients with Fungal Septicaemia

OBJECTIVE To study on the clinical features and treatment method for fungemia. METHODS The clinical features, therapy and outcome of 7 patients with fungemia which happened from 1999 to 2009 were retrospectively reviewed. RESULTS The main underlying conditions were : malignant disease in 7 patients (100%). In this group the risk factors for fungemia included: prior antimicrobial therapy (86%), steroids chemotherapy (57%). Fungal species isolated from 7 patients were: c. albicans (5), c. tropicalis (2). The overall mortality of fungemia was 86%. CONCLUSIONS In this study,the most frequent infectious agents were Candida albicans and non albicans Candida specis. Experience therapy should be begun earlier. Higher dose of fluconazole may be recommended in clinical usage.