Glucose Metabolism and Visceral Fat in GH Deficient Adults: Two Years of GH-Replacement |
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Authors: | Email author" target="_blank">Luciana?Diniz?Carneiro?SpinaEmail author Débora?Vieira?Soares Rosane?Resende?de?Lima?Oliveira?Brasil Priscila?Marise?Lobo Flávia?Lúcia?Concei??o Mário?Vaisman |
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Institution: | 1.Servi?o de Endocrinologia do Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina,Universidade Federal do Rio de Janeiro (UFRJ),Rio de Janeiro,Brasil;2.Rua José Linhares,Rio de Janeiro,Brasil |
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Abstract: | The aim of this study was to evaluate the effect of 24 months of growth hormone (GH) replacement on glucose metabolism and
visceral fat in 17 adults with GH deficiency: 9 men and 8 women; age 40 ± 1.8 yr. range 20–61] and body mass index 25 ± 0.8
Kg/m2.
Glucose metabolism was evaluated by a standard oral glucose tolerance test (OGTT), by the homeostatic model assessment (HOMA)
insulin resistance index and by the insulin sensitivity index (ISI)-composite derived from the OGTT. Visceral fat was evaluated
by CT scan.
Twenty-four months of GH replacement induced an increase in the prevalence of abnormal glucose tolerance, with significant
progressive increment in 2h-OGTT insulin levels at 3, 12 and 24 months (p = 0.005). Plasma glucose levels and ISI-composite did not alter during the study. HOMA-IR index increased only in the group
of patients (n = 8) who had abnormal OGTT at 24 months (p = 0.012). Visceral fat reduced at month 12 and remained decreased until the end of the study (p = 0.009).
In conclusion, the present study suggests that adults with GH deficiency after twenty-four months of GH replacement developed
abnormal glucose tolerance, probably due to an increase in insulin resistance, associated with higher insulin levels, despite
favorable alterations in body composition.
Research grant-FAPER.
Senior researcher-CNPQ. |
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Keywords: | glucose metabolism visceral fat GH deficiency in adults GH replacement |
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