抗菌药物应用与手术患者医院感染关系的队列研究

目的通过回顾性队列研究探讨预防性抗菌药物应用与外科手术患者医院感染的关系。方法回顾性调查2006年1-3月外科连续出院病例3221份,根据抗菌药物应用是否合理分为暴露组和非暴露组,统计分析2组医院感染发病率是否有差别。结果599例手术患者抗菌药物综合评价合理,抗菌药物合理应用率为18.6%,应用合理者(非暴露组)医院感染例次感染率为1.74%,不合理用药者(暴露组)医院感染例次感染率为3.51%,2组比较,P<0.05,有显著性差异。结论合理应用抗菌药物有利于控制耐药菌的产生,降低外科手术患者医院感染的发病率。

Retrospective cohort study on the relationship between antibiotics usage and nosocomial infections of patients underwent surgical operations

Objective To probe the relationship between prophylactic antibiotics and nosocomial infections of patients underwent surgical operations through the retrospective cohort study.Methods 3 221 cases continuously discharged from January 2006 to March 2006 in the surgical department were retrospectively investigated. All the cases were divided into two groups according to their antibiotics usage. Then the incidence rates of nosocomial infections between the two groups were statistically analyzed. Results The ratio of rational antibiotics usage was 18.6%. 1.74% of patients in the non-expose group were infected and 3.51% of patients in the expose group gained nosocomial infections. There was a significant difference between the two groups (P<0.05). Conclusions Rational antibiotics usage would control the appearance of multi-resistance bactesia and reduce the incidence rate of nosocomial infections.