长期他汀类药物的使用与冠心病患者心理障碍的关系

目的观察长期服用他汀药物对冠心病患者心理状态的影响。方法研究对象来自潍坊市人民医院心血管科及老年医学科,在入组时及随访中评价心理状况,干预因素为长期服用他汀药物,观察指标为抑郁、焦虑、敌对状态。计算优势比及95%置信区间代表他汀使用与异常心理评分的关联性。结果研究对象平均随访4年,最多随访7年,比较140例长期连续服用他汀药物患者的异常心理评分,在对基础状态进行校正后,优势比分别为抑郁（OR0.63,95%CI0.43～0.93）、焦虑（OR0.69,95%CI0.47～0.99）及敌对（OR0.77,95%CI0.58～0.93）。他汀药物的心理获益与胆固醇水平关系不大。结论冠心病患者长期他汀药物服用与抑郁、焦虑、敌对等心理状态好转有关。

Long-term Statin Use and Psychological Well-Being

Objective Study the effect of long-term statin use on psychometric measures in an adult population with underlying coronary artery disease （CAD）. Methods Study subjects were recruited from de- partment of geriatric and cardiovascular in Weifang people＇s hospital. Psychological well-being was assessed at baseline and annually during follow-up. The exposure of interest was long-term statin use and the outcomes of in- terest wer depression,anxiety and hostility. We estimated the odds ratios（ORs） and 95% confidence（CI） that represented the strength of association between statin use （vs. no use of any cholesterol-lowering drug） and the risk of having abnormal depression, anxiety, and hostility scores. Results Study subjects had an average follow- up of four years and maximum of seven years. Comparing the 140 patients who had continuous use of statins with lower risk of abnormal depression scores（ OR 0. 63,95% CI 0. 43 to 0. 93 ）, anxiety（ OR 0.69,95% CI 0. 47 to 0. 99 ）, and hostility（ OR0.77,95% CI 0. 58 to 0. 93 ） after adjustment for the propensity for statin use potential confounders. The beneficial psychological effects of the statins appeared to be independent of the drugs, choles- terol-lowering effects. Conclusion Long-term use of statins among patients with CAD appeared to be associated with reduced risk of anxiety, depression and hostility.