长期他汀类药物的使用与冠心病患者心理障碍的关系 |
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引用本文: | 马洪胜,马永盛,陈亮,吕秀云,李蕾. 长期他汀类药物的使用与冠心病患者心理障碍的关系[J]. 中国实用医药, 2013, 8(23): 15-16 |
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作者姓名: | 马洪胜 马永盛 陈亮 吕秀云 李蕾 |
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作者单位: | 马洪胜 (山东省潍坊市人民医院老年病科,261041); 马永盛 (山东省潍坊市人民医院老年病科,261041); 陈亮 (山东省潍坊市人民医院老年病科,261041); 吕秀云 (山东省潍坊市人民医院老年病科,261041); 李蕾 (山东省潍坊市人民医院老年病科,261041); |
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摘 要: | 目的观察长期服用他汀药物对冠心病患者心理状态的影响。方法研究对象来自潍坊市人民医院心血管科及老年医学科,在入组时及随访中评价心理状况,干预因素为长期服用他汀药物,观察指标为抑郁、焦虑、敌对状态。计算优势比及95%置信区间代表他汀使用与异常心理评分的关联性。结果研究对象平均随访4年,最多随访7年,比较140例长期连续服用他汀药物患者的异常心理评分,在对基础状态进行校正后,优势比分别为抑郁(OR0.63,95%CI0.43~0.93)、焦虑(OR0.69,95%CI0.47~0.99)及敌对(OR0.77,95%CI0.58~0.93)。他汀药物的心理获益与胆固醇水平关系不大。结论冠心病患者长期他汀药物服用与抑郁、焦虑、敌对等心理状态好转有关。
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关 键 词: | 他汀 冠心病 焦虑 抑郁 |
Long-term Statin Use and Psychological Well-Being |
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Affiliation: | MA Hong-sheng , MA Yong-sheng , CHEN Liang , et al( Department of senile disease of Weifang People' Hospital, Weifang 261041, China) |
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Abstract: | Objective Study the effect of long-term statin use on psychometric measures in an adult population with underlying coronary artery disease (CAD). Methods Study subjects were recruited from de- partment of geriatric and cardiovascular in Weifang people's hospital. Psychological well-being was assessed at baseline and annually during follow-up. The exposure of interest was long-term statin use and the outcomes of in- terest wer depression,anxiety and hostility. We estimated the odds ratios(ORs) and 95% confidence(CI) that represented the strength of association between statin use (vs. no use of any cholesterol-lowering drug) and the risk of having abnormal depression, anxiety, and hostility scores. Results Study subjects had an average follow- up of four years and maximum of seven years. Comparing the 140 patients who had continuous use of statins with lower risk of abnormal depression scores( OR 0. 63,95% CI 0. 43 to 0. 93 ), anxiety( OR 0.69,95% CI 0. 47 to 0. 99 ), and hostility( OR0.77,95% CI 0. 58 to 0. 93 ) after adjustment for the propensity for statin use potential confounders. The beneficial psychological effects of the statins appeared to be independent of the drugs, choles- terol-lowering effects. Conclusion Long-term use of statins among patients with CAD appeared to be associated with reduced risk of anxiety, depression and hostility. |
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Keywords: | Statin Coronary artery disease ,Depression anxiety |
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