Combined transplantation of GDAsBMP and hr-decorin in spinal cord contusion repair****○ |
| |
作者姓名: | Liang Wu Jianjun Li Liang Chen Hong Zhang Li Yuan Stephen JA Davies |
| |
作者单位: | School of Rehabilitation Medicine, Capital Medical University;Department of Neural Functional Reconstruction of Spine and Spinal Cord, China Rehabilitation Research Center;Rehabilitation Center, Beijing Xiaotangshan Rehabilitation Hospital;Department of Neurosurgery, University of Colorado Denver |
| |
基金项目: | supported by funding from the Ministry of Finance People’s Republic of China;China Rehabilitation Research Center Research Program grants, No. 2008-2,2008-3, 2008-4, 2008-5 |
| |
摘 要: | Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astrocytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, double-immunofluorescent histochemistry revealed that combined transplantation inhibited the early inflammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was secreted by transplanted cells, protected injured axons. The combined transplantation promoted axonal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte proliferation and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels.
|
关 键 词: | neural regeneration spinal cord injury astrocytes glial scar neural stem cells combined transplantation glial progenitor cells glial cells human recombinant decorin brain-derived growth factor glial fibrillary acidic protein grants-supported paper neuroregeneration |
收稿时间: | 2013-03-15 |
本文献已被 CNKI 等数据库收录! |
|