| 胸腺瘤组织中c-myc基因的表达及其意义 |
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| 引用本文： | 黄壮士,张艳峰,曾涟乾.胸腺瘤组织中c-myc基因的表达及其意义[J].肿瘤防治研究,2006,33(12):865-867. |
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| 作者姓名： | 黄壮士 张艳峰 曾涟乾 |
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| 作者单位： | 郑州大学第二附属医院胸外科; |
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| 摘 要： | 目的研究c-myc基因在胸腺瘤组织中的表达,探讨c-myc基因与胸腺瘤的发生发展、恶性程度的关系。方法应用免疫组织化学SP法,检测c-myc在41例胸腺瘤和18例非肿瘤胸腺组织中的表达,结合胸腺瘤WHO分型、Masaoka分期,研究c-myc基因在胸腺瘤各分型、分期中的表达情况。结果c-myc在胸腺瘤中的阳性表达率为63.4%,在非肿瘤胸腺组织中的阳性表达率为16.7%,两者间有统计学差异(P<0.01)。c-myc在良性胸腺瘤(A/AB型)和恶性胸腺瘤(B1~B3型)中的表达分别为30.0%和74.2%,两者有统计学差异(P<0.05)。c-myc在非侵袭性胸腺瘤(Ⅰ期)与侵袭性胸腺瘤(Ⅱ~Ⅳ期)中的表达分别为33.3%和75.9%,两者有统计学差异(P<0.05)。结论c-myc与胸腺瘤的发生发展有关;与胸腺瘤的恶性程度、侵袭性有关。
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| 关 键 词： | 胸腺瘤 c-myc WHO分型 Masaoka分期 |
| 文章编号： | 1000-8578（2006）12-0865-03 |
| 收稿时间： | 2005-11-14 |
| 修稿时间： | 2005-11-142005-12-09 |
The Significance and Expression of c-myc in Thymomas |
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| HUANG Zhuang-shi,ZHANG Yan-feng,ZENG Lian-qian.The Significance and Expression of c-myc in Thymomas[J].Cancer Research on Prevention and Treatment,2006,33(12):865-867. |
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| Authors: | HUANG Zhuang-shi ZHANG Yan-feng ZENG Lian-qian |
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| Institution: | Dept. of Thoracic Surgery; 2nd Affiliated Hospital; Zhengzhou University; Zhengzhou 450014; China; |
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| Abstract: | Objective To correlate the expression of c-myc in the thymomas with histological type, clinical stage. Methods c-myc’s expression in paraffin-embedded sections of 41 thymomas and 18 non-neoplastic thymus were detected by immunohistochemical SP assay. Results The positive rates of c-myc in thymomas and non-neoplastic thymus was 63.4% (26/41), 16.7% (3/18). And the different was significant (P< 0.01 ). The difference of c-myc positive rate in thymomas was significant between WHO histological type A/AB ( 30... |
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| Keywords: | c-myc |
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