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| 特比萘芬搽剂治疗浅部真菌病的疗效与体外药效学研究 | |
| 引用本文： | 王克玉,李春阳,沈永年,赵克宁,王福胜. 特比萘芬搽剂治疗浅部真菌病的疗效与体外药效学研究[J]. 山东大学学报(医学版), 2001, 39(4): 365-367 |
| 作者姓名： | 王克玉 李春阳 沈永年 赵克宁 王福胜 |
| 作者单位： | 1. 山东大学齐鲁医院皮肤科 2. 中国医学科学院皮肤病研究所 3. 潍坊市人民医院皮肤科 4. 烟台市毓璜顶医院皮肤科 |
| 摘 要： | 目的评价新剂型1%盐酸特比萘芬搽剂的疗效及安全性.方法将100例浅部真菌感染患者随机分为试验组对照组,试验组给予特比蔡芬搽剂外用,对照组外用联苯苄唑溶液.结果试验组与对照组的痊愈率分别为50.0%和30.0%,有效率分别为90.0%和75.0%,试验组的痊愈率与有效率均高于对照组(P<0.01).真菌消除率分别为83.0%和81.0%(P>0.05),说明两药抗菌效果均较好.不良反应发生率分别为14.0%和17.0%(P>0.05).体外研究表明,特比萘芬搽剂对临床试验所分离的6属9种147株常见真菌的MIC范围皮肤癣菌为0.04～0.16mg/l,念珠菌为0.08～0.63mg/l,优于联苯苄唑溶液.结论特比蔡芬搽剂治疗浅部真菌病疗效好,安全性高. |
| 关 键 词： | 特比萘芬 联苯苄唑 皮肤真菌病 疗效 MIC |
| 文章编号： | 1000-0496(2001)04-0365-03 |
| 修稿时间： | 2000-01-20 |
CLINICAL EFFECT OF TREBINAFINE LOTION IN THE TREATMENT OF DERMATOMYCOSES AND ITS PHARMACODYNAMICS IN VITRO |
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| WANG Ke yu,LI Chun yang,SHEN Yong nian,et al. CLINICAL EFFECT OF TREBINAFINE LOTION IN THE TREATMENT OF DERMATOMYCOSES AND ITS PHARMACODYNAMICS IN VITRO[J]. Journal of Shandong University:Health Sciences, 2001, 39(4): 365-367 | |
| Authors: | WANG Ke yu LI Chun yang SHEN Yong nian et al |
| Abstract: | Objective:To evaluate the safty and efficacy of the new formulation 1% terbinafine lotion in the treatment of dermatomycoses.Methods:Two hundreds patients with dermatomycoses were randomly divided into terbinafine and bifonazole groups.The former group were administered topically with terbinafine(twice daily),and the later group with bifonazole(once daily) for 2 weeks with tinnea corporis and tinea cruris,for 3 weeks with tinea mannus and tinea pedis.Results:The curative rates of terbinafine and bifonazole groups were 50.0% and 30.0% ( P<0 01) ,the efficacy rates 90.0% and 75.0% ( P<0 01) ,the mycological clearance rates 83.0% and 81.0%( P>0.05) ,respectively.Conclusion:Terbinafine lotion is a safe and effective drug in the treatment of dermatomycoses. |
| Keywords: | Terbinafine Bifonazole Dermatomycoses Effect MIC |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |