Comparative study of time-course of hemodynamic effect of isosorbide dinitrate spray and sublingual tablets in patients with pulmonary congestion |
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Authors: | Niccolo Marchionni Mauro De Bari Luigi Ferrucci Guya Moschi Adam Schneeweiss |
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Affiliation: | (1) Geriatric Coronary Care Unit, Florence, Italy;(2) Geriatric Cardiology Research Foundation, Tel-Aviv, Israel;(3) Geriatric Cardiology Research Foundation, 9 Kehilat Sofia St., 69018 Tel-Aviv, Israel |
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Abstract: | Summary We compared the time-course of the hemodynamic effect of isosorbide dinitrate (ISDN), 5 mg, in the form of sublingual tablet and oral spray, in 15 patients with isolated chronic pulmonary congestion (pulmonary arterial end-diastolic pressure of 15 mmHg or more in the presence of normal or only slightly reduced cardiac index). Both formulations produced significant reductions in the pulmonary arterial end-diastolic pressure. The effect of ISDN tablet (sublingually) became evident at 10 minutes after administration and was maximal at 30 minutes. The effect of ISDN oral spray became evident at 3 minutes and reached a peak at 10 minutes. The magnitude of hemodynamic response was similar. These findings indicate that ISDN oral spray is superior to ISDN sublingual tablets for rapid relief of pulmonary congestion |
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Keywords: | Isosorbide heart failure hemodynamics |
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