| 帕金森病抑郁相关因素研究及西肽普兰药物治疗的评价 |
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| 引用本文： | 欧阳锋,陈涛,文国强,吴惠玲,翁国虎.帕金森病抑郁相关因素研究及西肽普兰药物治疗的评价[J].海南医学,2010,21(1):6-8. |
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| 作者姓名： | 欧阳锋 陈涛 文国强 吴惠玲 翁国虎 |
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| 作者单位： | 海南省人民医院神经内科,海南,海口,570311 |
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| 摘 要： | 目的探讨帕金森病（PD）抑郁相关因素及应用西肽普兰药物治疗后的临床疗效及安全性。方法收集我院的PD患者共100例进行抑郁自评量表（SDS）、Haimilton抑郁量表（HAMD）、一般情况调查表及PD综合评分量表（UPDRS）的评定，对相关因素进逐步回归及偏相关分析；所有患者入院后进行SDS、HAMD评定后，筛选出抑郁症患者42例，随机分为治疗组和对照组，治疗组患者予西肽普兰治疗，对照组予谷维素治疗，观察其疗效及不良反应。结果100例PD患者中出现抑郁症状42例，占42．0％。伴发抑郁相关因素有性别、婚姻、家庭关系、UPDRSⅢ评分、多巴胺受体激动剂。应用西肽普兰治疗前后HAMD评分分别为23．7±2．8vs15．7±1．3；UPDRSⅢ评分分别为32．5±12．3vs22．8±10．5，治疗前后相比有显著性差异（P〈0．05）。治疗组有效率为80．9％，对照组为28．6％，两组比较差异有统计学意义（P〈0．05）。结论PD伴发抑郁的相关因素复杂，抑郁可能与社会心理、神经生物学相关，西肽普兰可改善PD抑郁症状且安全。
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| 关 键 词： | 帕金森病 抑郁 西肽普兰 |
Study of related factors of depression and evaluated the efficacy of citalopram in Parkinson disease |
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| Institution: | OU Yang - feng, CHEN Tao , WEN Guo - qiang , et al. (Department of Neurology, People＇ s Hospital of Hainan Province, Haikou ,570311, Hainan , CHINA) |
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| Abstract: | Objective To investigate the related factors of depression and the clinical efficacy and safety of citalopram in the treatment of Parkinson disease(PD). Methods 100 patients with PD were assessed by Hamiton Depression Rating Scales(HAMD),Self-Rating Depression Scale(SDS),a self-designed question and Unified PD Rating Scale (UPDRS). Related factors were analyzed by stepwise regression and partial correlation. After assessing,42 patients with depression were randomly divided into control group and therapy gro... |
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| Keywords: | Parkinson disease Depression Citalopram |
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