| 美国糜烂性毒剂损伤和救治研究项目及其进展 |
| |
| 引用本文： | 邹仲敏,赵吉清,赛燕,但国蓉,蔡颖,赵远鹏,叶枫,程晋,姜帆.美国糜烂性毒剂损伤和救治研究项目及其进展[J].军事医学科学院院刊,2012,36(6):460-464. |
| |
| 作者姓名： | 邹仲敏 赵吉清 赛燕 但国蓉 蔡颖 赵远鹏 叶枫 程晋 姜帆 |
| |
| 作者单位： | 第三军医大学军事预防医学院毒理学研究所,重庆,400038 |
| |
| 基金项目： | 全军医学科技"十二五"重大项目资助，军队"重大新药创制"科技重大专项资助项目 |
| |
| 摘 要： | 近年美国国立卫生研究院（NIH）资助的项目中,以研究中心承担主要任务,但各有侧重,可以满足转化医学研究的条件需求,也体现了NIH的先进管理理念。对糜烂性毒剂损伤和救治的研究包括损伤机制、药物研发、疗法评估等重要环节。目前在研的候选药物主要有抗炎药多西环素水凝胶、抗氧化剂（单/双硫醇、水飞蓟宾、AEOL10150）、亲核性清除剂（二硫嘌呤类和柔花酸）等。
|
| 关 键 词： | 糜烂性毒剂 芥子气 损伤机制 药物研发 美国国立卫生研究院 |
Research programs on vesicant injury and progress in the USA |
| |
| ZOU Zhong-min
,
ZHAO Ji-qing
,
SAI Yan
,
DAN Guo-rong
,
CAI Ying
,
ZHAO Yuan-peng
,
YE Feng
,
CHENG Jin
,
JIANG Fan.Research programs on vesicant injury and progress in the USA[J].Bulletin of the Academy of Military Medical Sciences,2012,36(6):460-464. |
| |
| Authors: | ZOU Zhong-min ZHAO Ji-qing SAI Yan DAN Guo-rong CAI Ying ZHAO Yuan-peng YE Feng CHENG Jin JIANG Fan |
| |
| Institution: | (Institute of Toxicology,College of Preventive Medicine,the Third Military Medical University,Chongqing 400038,China) |
| |
| Abstract: | In recent years,the American National Institutes of Health（NIH） has sponsored some major programs of vesicant research with a big budget.The programs are operating mainly in designated research centers with their specific research interest and tasks in order to meet the needs of translational medicine research,which indicates the superior administrative mechanism of NIH.Studies on vesicant countermeasures involve the damaging mechanism,antidote development and regimen evaluation.Some candidate drugs,such as doxycycline hydrogel,antioxidants（silibinin,monothiol,dithiol,AEOL10150）,nucleophilic scavenger（dithiopurines and ellagic acid）,have shown promising effect in alleviating the damage from vesicant exposure. |
| |
| Keywords: | vesicant mustard gas mechanism drug development National Institutes of Health |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
