高原化学毒剂伤的伤情特点和机制研究

系统回顾了高原化学毒剂伤伤情特点和发生机制研究进展。高原环境影响人体健康的主要因素是低压缺氧。在既往的20年内,国内外建立了一系列模拟高原缺氧的实验技术和模型。利用这些技术进行的实验研究结果表明,高原缺氧复合化学中毒时,缺氧和中毒两种因素同时作用于机体,使病理生理反应、毒物代谢过程、中毒表现及药物效应等发生变化,常规的救治方案是否合适,值得进行更深入地探讨。

Clinical features and their mechanism of chemical intoxications during exposure to high altitudes

The clinical features and their mechanism of chemical intoxications during exposure to high altitudes are comprehensively reviewed.Hypobaric hypoxia is a major undesirable factor that may produce injuries to the body during exposed to high altitudes.In the near twenty years,a series of technique and model have been established to effectively simulate the high altitude situation with hypobaric hypoxia.Results from the studies in these technique and models indicated a joined effect of the two factors,hypoxia and chemical intoxication.The physiopathologic parameters and chemical metabolism process were changed.Clinical manifestation and the efficacy of therapeutic drugs were also altered.These information suggest a need to evaluate the reliability of the conventional treatment scheme in the cases of combined injury of chemical intoxication and hypoxia.