CHP1002抗炎镇痛作用评价

目的研究穿琥宁经PEG修饰的新化合物CHP1002的抗炎镇痛作用。方法分别采用小鼠耳肿胀实验、大鼠足肿胀实验、小鼠醋酸扭体实验观察不同剂量（220,440,880 mg/kg）CHP1002的抗炎镇痛作用,以及给药后不同时间与原型药物的抗炎药效的比较。结果动物腹腔注射CHP1002 440、880 mg/kg剂量组具有抗炎作用（P〈0.01）,皮下注射CHP1002 440、880 mg/kg剂量组具有镇痛作用（P〈0.01）。在给药后不同时间,CHP1002比原型药物的抗炎和镇痛作用延长（P〈0.05）。结论经PEG修饰的化合物CHP1002具有抗炎镇痛作用,其作用时间要长于原型药物。

Anti-inflammatory and analgesia effect evaluation of CHP1002

Objective To evaluate the anti-inflammatory and analgesia effect of a PEG modified compound CHP1002 on animal models.Methods Using the ear swelling test in mice,the paw edema test in rats,and the acetic acid-induced pain test in mice,the anti-inflammatory effect of CHP1002（220,440 and 880 mg/kg） was evaluated and its anti-inflammatory and analgesia effect was compared with the prototype drug at different time after administration.Results In all the three animal models,the anti-inflammatory effect of CHP1002（440 and 880 mg/kg）（P0.01）was observed,and subcutaneous injection had analgesia effect（P0.01）.In comparison with the prototype drug,the anti-inflammatory and analgesia effect of CHP1002 was prolonged at different time after administration（P0.05）.Conclusion The PEG modified compound CHP1002 has anti-inflammatory and analgesia effect and prolongs the action time.