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Exposure to magnetic resonance imaging does not produce taste aversion in rats
Authors:J M Messmer  J H Porter  P Fatouros  U Prasad  M Weisberg
Affiliation:1. Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, CH-3000 Bern 60, Switzerland;2. Rhinology, Smell and Taste Outpatient Clinic, Department of Otorhinolaryngology Head and Neck Surgery, Bern University Hospital, Inselspital, Freiburgstrasse, CH-3010 Bern, Switzerland;3. Psychiatric Neuroimaging Unit, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, CH-3000 Bern 60, Switzerland;4. Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California Los Angeles, 90095 Los Angeles, CA, USA;5. Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan;6. Rhinology–Olfactology Unit, Department of Otorhinolaryngology, Geneva Neuroscience Center (CMU), University of Geneva Hospitals, Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva 14, Switzerland;7. Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland;1. Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, Maastricht 6200 MD, The Netherlands;2. Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
Abstract:A taste aversion test was used to evaluate possible toxic effects of magnetic resonance imaging (MRI). Thirty male Sprague-Dawley rats were randomly assigned to four groups: Group One (n = 10) received 30 minutes exposure inside the MRI scanner; Group Two (n = 10) received a sham exposure to the MRI scanner; Group Three (n = 5) was injected with 0.15 M lithium chloride; and Group Four (n = 5) was injected with vehicle. All groups were given 10 minutes access to a 0.1% saccharin solution immediately prior to their respective treatment. The rats treated with lithium chloride displayed a taste aversion to the saccharin solution upon subsequent testing over an eight day period. The two control groups (Two and Four) and the rats exposed to MRI did not display any aversion to the saccharin solution. These results are compared to other studies that have shown that magnetic fields can influence biological systems.
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