The predictors of cholelithiasis in female patients with metabolic syndrome |
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Authors: | Doina-Clementina Cojocaru Florin Mitu Cristina Gena Dascălu Alina Manole Corina Dima-Cozma |
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Affiliation: | 1. Ist Medical Department, Faculty of Medicine, Iasi, Romania 4. University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania 2. Medical Informatics and Biostatistics Department, Faculty of Dental Medicine, Iasi, Romania 3. Primary Health Care and Epidemiology Department, Faculty of Medicine, Iasi, Romania
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Abstract: | Cholesterol gallstone disease is often associated with the metabolic syndrome. Female gender is an unmodifiable risk factor for cholelithiasis and, in its turn, the metabolic syndrome features a sexual dimorphism which warns that a global approach might overlook important discrimination. We carried out a retrospective analytical case-control study in order to perform a comparative analysis between two groups of female patients with metabolic syndrome and gallstones (n=60) or without gallstones (n=65). All the patients were investigated by abdominal ultrasound and met at least three criteria for the diagnosis of metabolic syndrome. Cases and controls were compared regarding anthropometric measurements, a complex lipid profile, and liver function tests. The risks associated with the likelihood of gallstones were estimated by means of cross-tabulation. In order to rank the significant variables we developed a binary logistic regression model which identified lean body weight ≤ 46.44 kg (OR 0.165; 95% CI 0.045–0.611; P = 0.007), total cholesterol ≥ 4.9 mmol/L (OR 15.948; 95% CI 2.700–94.205; P = 0.002), and direct bilirubin > 5.1 µmol/L (OR 0.056; 95% CI 0.013–0.235; P < 0.001), as variables with significant probability of association with the risk of gallstones in women with metabolic syndrome. |
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