Anti-U and haemolytic disease of the fetus and newborn |
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Authors: | G. Smith Consultant Haematologist,P. Knott Consultant Obstetrician,&dagger ,J. Rissik Associate Specialist in Neonatology,,J. de la,Fuente Paediatric Senior House Officer&Dagger ,N. Win Consultant Haematologist,§ |
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Affiliation: | Haematology Department, Guy's Hospital;Neonatal Unit, Guy's Hospital;Directorate of Women's Health Services, Lewisham Hospital;Neonatal Unit, Lewisham Hospital;South Thames Centre of the National Blood Service, London |
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Abstract: | The red cell alloantibody, anti-U, is uncommon but is a recognised cause of haemolytic disease of the fetus and newborn. We describe six pregnancies complicated by the presence of maternal anti-U, and review nine other well-documented cases. In these 15 cases severe haemolytic disease occurred only with titres of ≥ 1/512, and titres as high as 1/4000 were not necessarily associated with significant haemolysis. We recommend that an anti-U titre of ≥ 1/128 or more at ≥ 17 weeks of gestation is an indication for assessment of haemolysis in the fetus. Amniocentesis is the preferred initial investigation. |
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