血小板增高与胃癌患者预后关系研究

目的:研究胃癌患者术前血小板计数与其手术后预后的关系。方法:回顾性分析天津医科大学附属肿瘤医院1995年1 月至1999年12月间，经手术治疗的胃癌初治患者782 例临床资料并进行随访，比较血小板增高情况对患者生存预后的影响，应用Kaplan-Meier 法进行生存分析并行Log-rank 检验，Cox 多因素回归分析患者血小板增高及其他临床因素对预后的影响。结果:本组胃癌患者血小板增高发生率为11.4%（89/782），血小板增高发生率在不同性别、临床分期及组织分化之间差异无统计学意义（P>0.05），仅在不同年龄之间差异存在统计学意义（P<0.05）。 无血小板升高与血小板升高的患者1、3、5 年生存率分别为75.0%vs 52.8%（P<0.01）、40.1% vs 16.9%（P<0.01）、28.9% vs 13.5%（P=0.002）。 单因素分析显示，临床组织分化类型、病理分期、手术方式显著影响患者生存，而年龄、性别对生存期无显著影响。进一步多因素分析显示，临床分期、手术方式及血小板计数是影响预后的独立因素，血小板升高的患者相对危险度（RR=1.454，95%CI:1.135～1.861，P=0.005）表明血小板升高患者死亡危险为血小板无升高者的1.454 倍。结论:血小板增高是影响胃癌初治患者生存的独立预后因素。 

The Association of Thrombocytosis with the Prognosis of Patients with Gastric Cancer

Objective: To analyze the association of thrombocytosis with the prognosis of patients with gastric cancer.Methods: The clinical materials of 782 patients with gastric cancer who underwent initial surgery in our hospital between January 1995 and December 1999 were retrospectively analyzed.Kaplan- Meier and Log-Rank test were used to analyze the data.Prognostic factors were analyzed by multivariate Cox proportional hazards model.Results: Thrombocytosis oc-curred in 11.4% (87/782) patients.The platelet level was not significantly different among patients of different gender, tumor stage, and histological differentiation (P>0.05).However, a significant difference was observed in the platelet level among patients with different age and surgical approach (P<0.05).The 1-, 3-, and 5-year survival rates were 75.0%, 40.1% and 28.9% in patients without thrombocytosis and 52.8%, 16.9%, and 13.5% in patients with thrombocytosis (P=0.002).Univari-ate analysis showed that histological differentiation, pathological stage, surgical approach and thrombocytosis significantly affected the survival of patients.While age and gender had no significant impact on patient survival.Multivariate analysis showed that pathological stage, surgical approach, and thrombocytosis were independent prognostic factors for gastric can-cer.The relative risk of death of patients with thrombocytosis was elevated by 1.454 times (RR=1.454, 95% CI: 1.135～1.861, P=0.005).Conclusion: Thrombocytosis is an independent prognostic indicator for the survival of initially treated pa-tients with gastric cancer.