| 大鼠脊髓损伤后bFGF、EGF海绵对内源性神经干细胞的诱导及修复作用 |
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| 引用本文： | 刘海,洪涛,王忠诚,安沂华,崔勇. 大鼠脊髓损伤后bFGF、EGF海绵对内源性神经干细胞的诱导及修复作用[J]. 中国康复理论与实践, 2007, 13(6): 501-503 |
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| 作者姓名： | 刘海 洪涛 王忠诚 安沂华 崔勇 |
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| 作者单位： | 1. 首都医科大学附属北京天坛医院,北京市,100050
2. 安顺市人民医院神经外科,贵州安顺市,561400 |
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| 基金项目： | 北京市科技新星计划项目 |
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| 摘 要： | 目的探讨碱性成纤维细胞生长因子（bFGF）、表皮生长因子（EGF）海绵植入损伤脊髓对脊髓损伤后内源性干细胞的诱导修复作用。方法采用脊髓半横断制作脊髓损伤模型,将46只大鼠分为对照组（n=6,不损伤脊髓）、模型组（n=20）和实验组（n=20,造模后应用bFGF、EGF海绵治疗）,对3组动物进行行为学评分、电生理、电镜及免疫组化检测。结果实验组动物经bF-GF、EGF海绵治疗后,运动功能高于模型组,内源性神经干细胞数量多于模型组（P〈0.05）。结论bFGF、EGF海绵干预可促进脊髓损伤动物内源性神经干细胞增殖、分化,改善受损的脊髓功能。
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| 关 键 词： | 脊髓损伤 碱性成纤维细胞生长因子、表皮生长因子海绵 内源性神经干细胞 大鼠 |
| 文章编号： | 1006-9771（2007）06-0501-03 |
| 收稿时间： | 2007-05-08 |
| 修稿时间： | 2007-05-08 |
Induction and Repair of bFGF and EGF Sponge to Endogenous Neural Stem Cells after Half Cut-off of Spine Cord in Rats |
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| LIU Hai, HONG Tao , WANG Zhong-cheng , et al. Induction and Repair of bFGF and EGF Sponge to Endogenous Neural Stem Cells after Half Cut-off of Spine Cord in Rats[J]. Chinese Journal of Rehabilitation Theory and Practice, 2007, 13(6): 501-503 |
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| Authors: | LIU Hai HONG Tao WANG Zhong-cheng et al |
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| Affiliation: | Beijing TianTan Hospital, the Capital Medical University, Beijing 100050, China |
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| Abstract: | Objective To investigate induction and repair of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) sponge to endogenous neural stem cells after acute spinal cord half cut-off in rats.MethodsThe differences of proliferation and differentiation of endogenous neural stem cells were compared between injured group and intervention treatment group.ResultsThere are remarkable differences between the injured group and intervention treatment group.ConclusionbFGF and EGF sponge can enhance the proliferation and differentiation of the neural stem cells in the test animal. |
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| Keywords: | spinal cord injury basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) sponge endogenous neural stem cell rat |
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