2型糖尿病伴非酒精性脂肪肝患者胰岛功能及血脂分析

目的 探讨新诊断2型糖尿病(T2DM)患者中非酒精性脂肪肝（NAFL）与血脂、胰岛素抵抗及胰岛功能的关系。 方法 所有患者行OGTT试验，比较54例T2DM伴NAFL患者和48例T2DM不伴NAFL患者的体质指数（BMI）、血脂、血糖、胰岛素抵抗及胰岛功能，并进行多元回归分析。 结果 T2DM 伴NAFL组BMI，TC，TG，LDL-C，F-INS，P-INS，HOMA-IR显著高于不伴NAFL组（p<0.05）；△I30/△G30低于不伴NAFL组（p<0.05），TG及HOMA-IR均为NAFL的独立危险因素。结论 新诊断2型糖尿病伴NAFL患者，具有血脂紊乱，胰岛素抵抗及胰岛功能早期相分泌受损更严重的特点。

Analysis of islet function and the level of blood lipid in type 2 diabetes & non-alcoholic fatty liver disease

Objective To investigate the relationship between non-alcoholic fatty liver disease (NAFL) and the indices including the level of blood lipid, insulin resistance and islet function in type 2 diabetes(T2DM). Methods All subjects were tested with OGTT. Then, Body mass index (BMI), the level of blood lipid, blood glucose, insulin resistance and islet function in 54 T2DM with NAFL were compared with that in 48 T2DM without NAFL, followed by a multiple regression analysis. Results The levels of BMI, TC, TG, LDL-C, HDL-C, F-INS, P-INS and HOMA-IR in T2DM with NAFL were significantly higher than that in T2DM without NAFL（p<0.05）, while △I30/△G30 of the former lower than the latter. TG and HOMA-IR were both the independent risk factors of NAFL. Conclusion The patients of T2DM &; NAFL had characteristics of a more serious blood lipid disorder, a higher insulin resistance and a more severe impairment of early phase insulin secretion.