七氟醚复合芬太尼在成人麻醉诱导气管内插管中的应用

目的:观察七氟醚复合不同剂量芬太尼在成人麻醉诱导气管内插管中的应用。方法:60例择期手术患者随机均分为3组,均采用潮气量法吸入8%的七氟醚麻醉诱导,待患者自主呼吸,睫毛反射消失后,Ⅰ组复合静脉滴注芬太尼2μg·kg-1;Ⅱ组复合静脉滴注芬太尼3μg·kg-1、Ⅲ组复合静脉滴注芬太尼4μg·kg-1。记录各组麻醉诱导中睫毛反射消失时间和麻醉诱导前(T0)、气管内插管前(T1)、插管即刻(T2)、插管后1min(T3)、插管后3min(T4)、插管后5min(T5)、插管后10min(T6)各时点的收缩压(SBP)、舒张压(DBP)和心率(HR)变化及不良反应。结果:与T0时点比较,T1时点时,3组SBP、DBP、HR明显下降(P<0.01或P<0.05),Ⅲ组SBP和HR分别低于80mmHg和60bpm;T2时点时,Ⅰ组SBP、DBP、HR明显升高(P<0.01),但Ⅱ组变化不明显(P>0.05),Ⅲ组SBP、DBP、HR明显降低(P<0.01)。结论:吸入浓度为8%七氟醚复合3μg·kg-1的芬太尼可以很好的用于成人气管内插管麻醉的诱导。

Application of Sevoflurane Combined with Fentanyl in General Anesthesiainducing Endotracheal Intubation in Adults

OBJECTIVE：To observe the application of sevoflurane combined with different dose of fentanyl in general anesthesia-inducing endotracheal intubation in adults. METHODS：60 selective patients were randomly divided into three groups（n=20）. In haled 8% sevoflurane inductal anesthesia with tidal volume method. When the patients breathing and his own,and loss of eyelvaisah i .rve.f lTehxe, SgBroPu,p DⅠBwP earne dg iHvRen in2 eμagc·hk ggr-o1 ufpe nwtaenrye l dveitae cit.evd., agt rtoimupe Ⅱof 3lo sμsg-· okf-g -ey1 efleanstha nryelf lvexia ain.vd. baenfdo rger oinudpu Ⅲcti o4n μagn·esktgh-e1s ifae（ntTan0）y,l before intubation（T1）,at the moment of intubation（T2）,at 1 min after intubation（T3）,3 min after intubation（T4）,5 min after intubation（T5）and 10 min after intubation（T6）. RESULTS：Compared with at T0,SBP,DBP and HR in three groups were significantly decreased at T1（P0.01 or P0.05）. In group Ⅲ SBP was lower than 80 mmHg and HR was lower than 60 bpm. SBP, DBP and HR in groupⅠ were increased markedly at T2（P0.01）there was no obvious change in groupⅡ at T2（P0.05）. SBP, fDeBntPa naynld i sH eRff einc tigvreo utop iⅢnd uwceer ea ndeescthreeassiae di nm aadrukletd elyn daot trTa（2chPeal 0in.0t1u）b.a tCioOnN.CLUSION：Inhalation with 8% sevoflurane and 3 ug·kg-1