Role of nitric oxide in the regulation of activity of proteinase inhibitors α1-antitrypsin and α2-macroglobulin by capsaicin-sensitive nerves |
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| Authors: | V. K. Spiridonov Z. S. Tolochko |
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| Affiliation: | (1) Laboratory of Functional Neuromorphology, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |
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| Abstract: | Regulation of activity of serine proteinase inhibitor α1-antitrypsin and nonspecific proteinase inhibitor α2-macroglobulin in the blood by nitric oxide was studied in intact rats and animals with damage to capsaicin-sensitive nerves. Nonselective nitric oxide synthase inhibitor L-NAME produced a dose-dependent increase in α1-antitrypsin activity in intact animals. Neuronal NO synthase inhibitor 7-nitroindazole increased α 2-macroglobulin activity. Deafferentation with capsaicin was followed by a decrease in α1-antitrypsin activity. Both inhibitors of nitric oxide synthase increased activity of α1-antitrypsin in capsaicin-receiving rats. Nitric oxide precursor L-arginine had a normalizing effect on reduced activity of α1-antitrypsin after capsaicin deafferentation. Our results suggest that nitric oxide has a modulatory effect on activity of proteinase inhibitors and is involved in the effector influence of capsaicin-sensitive nerves on α1-antitrypsin activity. Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 9, pp. 350–354, September, 2008 |
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| Keywords: | capsaicin nitric oxide α 1-antitrypsin α 2-macroglobulin |
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