| 四氢喹啉类化合物的合成及其镇痛活性研究 |
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| 引用本文： | 刘永福,吴丽颖,刘秀洁,王玉玲,宋宏锐.四氢喹啉类化合物的合成及其镇痛活性研究[J].中国药物化学杂志,2007,17(3):144-147. |
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| 作者姓名： | 刘永福 吴丽颖 刘秀洁 王玉玲 宋宏锐 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的寻找具有镇痛活性的新型四氢喹啉类化合物,探讨4-（1H-吡咯-2-基）-1,2,3,4-四氢喹啉类化合物镇痛作用的构效关系。方法以4-（1H-吡咯-2-基）-1,2,3,4-四氢喹啉类化合物为母体,合成系列化合物。用醋酸致小鼠扭体法测定该类化合物的镇痛活性。结果与结论合成了20个新化合物,经1H-NMR和MS确证其结构。镇痛活性试验表明,所合成的部分化合物具有明显的镇痛作用,值得进一步研究。
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| 关 键 词： | 1 2 3 4-四氢喹啉 镇痛活性 构效关系 |
| 文章编号： | 1005-0108（2007）03-0144-04 |
| 收稿时间： | 2006-11-02 |
| 修稿时间： | 2006-11-02 |
Synthesis and analgesic activities of 4-(1H-pyrrol-2-yl)-tetrahydroquinoline derivatives |
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| LIU Yong-fu,WU Li-ying,LIU Xiu-jie,WANG Yu-ling,SONG Hong-rui.Synthesis and analgesic activities of 4-(1H-pyrrol-2-yl)-tetrahydroquinoline derivatives[J].Chinese Journal of Medicinal Chemistry,2007,17(3):144-147. |
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| Authors: | LIU Yong-fu WU Li-ying LIU Xiu-jie WANG Yu-ling SONG Hong-rui |
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| Institution: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Aim To search for new potent analgesic agents with tetrahydroquinoline structure and to study the structure-activity relationship(SAR) of the title compounds.Methods A series of 4-(1H-pyrrol-2-yl)-tetrahydroquinoline derivatives was prepared with a new synthetic route.Their analgesic activities were tested by acetic acid-induced mice writhing model.Results and conclusion Twenty new compounds were synthesized and their structures were confirmed by 1H-NMR and MS.Some of the target compounds showed remarkable analgesic activities.Some target compounds show potent analgesia activities and could be regarded as valuable compounds for further study. |
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| Keywords: | tetrahydroquinoline analgesic activity structure-activity relationship |
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