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Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone |
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| Authors: | Nyce, Jonathan W. Magee, Peter N. Hard, Gordon C. Schwartz, Arthur G. |
| Affiliation: | 1Fels Research Institute Philadelphia, PA 19140, USA 2Department of Pathology Philadelphia, PA 19140, USA 3Department of Microbiology, Temple University Medical School Philadelphia, PA 19140, USA |
| Abstract: | Long-term administration of dehydroepiandrosterone (DHEA) toBalb/c mice significantly inhibits the rate of appearance of1,2-dimethylhydrazine (DMH)-induced macroscopic colon and analrumors and microscopic precursor and malignant lesions. Thesteroid, which has previously been shown to inhibit spontaneousbreast cancer and chemically induced lung tumors in mice, mayfind application as a chemopreventive in individuals at highrisk for developing colon cancer. |
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