溃疡性结肠炎患者血清IL-23和IL-17的水平变化及意义

目的:探讨溃疡性结肠炎(UC)血清IL-23和IL-17的水平变化及其临床意义。方法:收集经临床明确诊断的UC患者54例,并选择同期健康体检者30例作为对照组。采用酶联免疫吸附法(ELISA)检测两组血清IL-23和IL-17的水平。结果:UC组患者血清IL-23和IL-17水平明显高于对照组,差异有显著统计学意义(t=18.76,21.48,P<0.01)。在轻度、中度、重度UC患者血清中,IL-23和IL-17的浓度水平均呈逐渐升高趋势,重度患者高于中度患者,中度患者高于轻度患者,三组间比较存在显著差异(P<0.05或0.01)。IL-23和IL-17在溃疡性结肠炎患者血清中的表达呈正相关(r=0.548,P<0.01)。结论:IL-23与IL-17的高表达可能参与了UC的慢性炎症形成过程;两者表达水平有密切相关性,IL-23可能通过诱导IL-17的产生而使后者在UC的发病中发挥作用。

Serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance

AIM:To study the serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance.METHODS:40 patients with ulcerative colitis as UC group and 30 healthy people as control group were selected.The serum contents of IL-23 and IL-17 were determined bll ELISA.RESULTS:Serum contents of IL-23 and IL-17 in UC group were higher than those in control group significantly(t=18.76,21.48,P<0.01).Serum contents of IL-23 and IL-17 increased with the clinical symptoms.Serum contents of IL-23 and IL-17 in severe patients were higher than those of mild and moderate patients significantly,and serum contents of IL-23 and IL-17 in mild patients were higher than those of moderate patients significantly.Serum contents of IL-23 were positively correlated to IL-17 significantly(r=0.548,P<0.01).CONCLUSION:IL-23 and IL-17 participates in the pathogenesis of ulcerative colitis.IL-23 may play a critical role in the development of UC through inducing production of IL-17.