A back-scattered electron microscopy (BSEM) study of the tight apposition between bone and hydroxyapatite coating |
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Authors: | Antonio Merolli Paolo Tranquilli Leali Ernesto De Santis |
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Institution: | (1) Orthopedics Clinic, Catholic University, Largo Gemelli 8, I-00168 Rome, Italy, Tel./Fax: +39-06-3313425, E-mail: amerolli@mail.nexus.it, IT |
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Abstract: | We performed a back-scattered electron microscopy analysis of the interface between newly formed bone and hydroxyapatite
coating, in an experimental rabbit model. Twenty cylinders made of Ti6A14V and coated with hydroxyapatite at different crystallinity
were implanted in the distal femural canal and retrieved at 4, 8, 26 an 34 weeks. Crystallinity of the coating varied from
90% to 60% and thickness varied between 50 and 100 μm. Osteocytes were detectable a few micrometers in proximity of the coating.
They produced new bone which was so tightly apposed to the coating that high magnification BSEM did not resolve any discontinuity
at the interface. This was not observed in uncoated implants. Degradation of the hydroxyapatite coating is not a simple hydrolytic
process because newly formed bone is remodelled in areas were a tight apposition with hydroxyapatite is present. The coatint
itself is likely to be attacked by the resorptive action of multinucleated giant cells and osteoclasts. In conclusion, response
to coated samples is morphologically characterized by tight apposition with bone. The substitution of areas of the coating
by newly formed bone is possible.
Received: 28 April 2000/Accepted: 2 June 2000 |
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Keywords: | Hydroxyapatite Bone Interface Electron microscopy |
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