Impairment of nasal airway under intermittent hypoxia during growth period in rats |
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Authors: | Yoichiro Kuma Risa Usumi-Fujita Jun Hosomichi Shuji Oishi Hideyuki Maeda Hisashi Nagai Yasuhiro Shimizu Sawa Kaneko Chisa Shitano Jun-ichi Suzuki Ken-ichi Yoshida Takashi Ono |
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Institution: | 1. Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan;2. Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;3. Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
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Abstract: | ObjectiveTo clarify the influences of intermittent hypoxia (IH) on the growth and development of the midfacial area, including the nasal cavity, in growing rats.DesignSeven-week-old male Sprague–Dawley rats were divided into two groups: the experimental group (n = 5), which was exposed to IH for 8 h during light periods at a rate of 20 cycles/h (nadir, 4% O2 to peak, 21% O2 with 0% CO2), and the control group (n = 5), which was exposed to room air. After 3 weeks, the maxillofacial structures in both groups were evaluated with respect to the height, width, length, surface area, cross-sectional area, and volume of the nasal cavity using soft X-ray and micro-CT.ResultsThe experimental group showed a significantly smaller cross-sectional area and volume than did the control group. The surface area exhibited no significant differences between the two groups, although it tended to be smaller in the experimental group than in the control group. The nasal volume divided by the length of the tibia (for comparison with whole-body growth) was significantly smaller in the experimental group than in the control group.ConclusionsThese data suggest that IH exposure suppresses growth and development of the nasal cavity and may result in nasal breathing disturbance. |
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Keywords: | Paediatric obstructive sleep apnoea Intermittent hypoxia Nasomaxillary complex Micro-CT |
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