Anti-ageing effects of dentifrices containing anti-oxidative,anti-inflammatory,and anti-bacterial agents (Tomarina) on gingival collagen degradation in rats |
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Authors: | Koichiro Irie Takaaki Tomofuji Daisuke Ekuni Yasumasa Endo Kenta Kasuyama Tetsuji Azuma Naofumi Tamaki Toshiki Yoneda Manabu Morita |
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Affiliation: | 1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;2. Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan |
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Abstract: | ObjectivePrevious studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) to the gingival surface on gingival collagen degradation in rats.DesignFischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina® (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months.ResultsIn the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p < 0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p < 0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months.ConclusionThese findings indicate that Tomarina® might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model. |
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Keywords: | ROM, reactive oxidative metabolites ROS, reactive oxygen species |
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