| MCM5和Ki67在宫颈上皮内瘤变及宫颈癌组织中表达及意义 |
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| 引用本文： | 陈玮,赵涌.MCM5和Ki67在宫颈上皮内瘤变及宫颈癌组织中表达及意义[J].第三军医大学学报,2007,29(14):1436-1439. |
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| 作者姓名： | 陈玮 赵涌 |
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| 作者单位： | 重庆医科大学基础医学院病理学教研室,重庆,400016 |
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| 摘 要： | 目的探讨微小染色体维持蛋白-5（minichromosome maintenance-5,MCM5）和Ki67在宫颈上皮内瘤变（cer-vical intraepithelial neoplasia,CIN）及宫颈癌组织中的表达及临床病理意义。方法采用免疫组化技术（S-P法）检测MCM5和Ki67在99例宫颈CIN和宫颈癌中的表达。结果MCM5和Ki67在正常宫颈黏膜上皮、CINⅠ-Ⅱ级、CINⅢ级、浸润癌表达的阳性率分别为26.7%、72.0%、80.0%、97.9%和10.0%、32.4%、84.0%、97.9%。各级CIN与浸润癌相比MCM5的表达率差异具有显著性（P〈0.05）;在CINⅢ级和宫颈癌中MCM5的表达与Ki67表达呈正相关（r=0.687,0.936,P〈0.05）。MCM5和Ki67表达率与临床分期及病理分级有关（P〈0.05）。结论MCM5和Ki67可作为反映宫颈上皮增生病变程度及生物学行为的指标,对宫颈非浸润性病变与浸润性病变的诊断及鉴别有参考价值。
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| 关 键 词： | MCM5 Ki67 宫颈癌 CIN 免疫组织化学 |
| 文章编号： | 1000-5404（2007）14-1436-04 |
| 修稿时间： | 2006-07-282007-01-15 |
Expressions of MCM5 and Ki67 in cervical intraepithelial neoplasia and cervical cancer and their clinical significance |
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| CHEN Wei,ZHAO Yong.Expressions of MCM5 and Ki67 in cervical intraepithelial neoplasia and cervical cancer and their clinical significance[J].Acta Academiae Medicinae Militaris Tertiae,2007,29(14):1436-1439. |
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| Authors: | CHEN Wei ZHAO Yong |
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| Institution: | Department of Pathology, Institute of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | |
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| Keywords: | MCM5 Ki67 cervical cancer cervical intraepithelial neoplasia immunohistochemistry |
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