不同预变性时间大鼠神经移植的研究

目的 观察大鼠不同预变性时间神经移植性对神经再生的影响。方法 以Ｗｉｓｔａｒ大鼠为实验动物，左侧腓总神经做移植供体，修复右侧腓总神经缺损。预变性时间分别为１、２、３周。术后分别于６、１０周进行检测。通过电生理学，组织学计量，胫前肌指数和电镜超微结构来评价神经再生的结果。结果 预变性组神经移植后神经再生的电生理学，组织学，组织学计量，胫前肌指数优于新鲜神经移植，术后６周电镜可观察到有髓鞘发育良好的轴

Study on nerve autografts of different predegenerated time to treat nerve defects

Objective To investigate the effect of nerve autografts with different predegenerated time on the outcome of nerve regeneration. Methods The Wistar rats were used as experimental animals. The left common peroneal nerve served as donor to repair the defect of the right common peroneal nerve. The predegenerated time was 1 week, 2 week and 3 week respectively. The detection was performed 6 week and 10 week after operation. The outcome of the nerve regeneration was evaluated electrophysiologically, histologically and microscopically. Results The outcome of nerve regeneration in predegenerated nerve grafts was better than that of fresh nerve graft; Three week predegenerated nerve grafts was obtained the best regeneraiton outcome among the groups. Conclusion The predegenerated nerve graft could be used as an ideal material for nerve transplantation. Three week for predegeneration was an optimal time.