| 槲皮素磷酸酯钾对血小板激活时钙流动的影响(英文) |
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| 引用本文： | 杜文民,汤允昭,王志平,张轩萍.槲皮素磷酸酯钾对血小板激活时钙流动的影响(英文)[J].中国医学生物技术应用,2002(1). |
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| 作者姓名： | 杜文民 汤允昭 王志平 张轩萍 |
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| 作者单位： | 上海市药品不良反应监测中心，山西医科大学药理教研室，山西医科大学药理教研室，山西医科大学药理教研室 200040，中国，太原，030001，中国，太原，030001，中国，太原，030001，中国 |
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| 摘 要： | 目的:研究槲皮素磷酸酯钾对血小板激活时钙流动的影响 方法:用荧光钙离子指示剂Fura-2观察槲皮素磷酸酯钾对血小板胞浆游离钙的影响。结果:槲皮素磷酸酯钾明显抑制凝血酶诱导的血小板游离钙的升高,减低细胞外钙内流,对细胞内储钙释放和非特异性钙内渗无影响。结论:抑制钙内流是槲皮素磷酸酯钾抑制血小板激活时胞浆Ca2 ]I 升高和抑制血小板功能的机制。
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| 关 键 词： | 槲皮素磷酸酯钾 凝血酶 血小板 钙 |
EFFECTS OF POTASSIUM QUERCETIN PHOSPHATE ON CALCIUM MOVEMENT OF ACTIVATED PLATELET |
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| Du Wenmin,Tang Yunzhao,Wang Zhiping,Zhang XuanPing.EFFECTS OF POTASSIUM QUERCETIN PHOSPHATE ON CALCIUM MOVEMENT OF ACTIVATED PLATELET[J].The Chinese Academic Medical Magazine of Organisms,2002(1). |
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| Authors: | Du Wenmin Tang Yunzhao Wang Zhiping Zhang XuanPing |
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| Institution: | Du Wenmin1 Tang Yunzhao2 Wang Zhiping2 Zhang XuanPing2 1 |
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| Abstract: | AIM: To study the effects of PQP on calcium movement of activated platelet METHODS: Using Fura-2 fluorescence technique. RESULTS: PQP inhibited the rise of Ca2 ]i induced by thrombin in platelets. This is because that PQP reduced the influx of extracellular calcium. But PQP had no effect on thrombin-induced internal Ca2 release from dense tubular system and extracellular calcium non-specific endosnosis. CONCLUSION: The inhibitory effect of PQP on the rise of Ca2 ]i in platelets was mainly due to an inhibition of Ca2 influx. |
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| Keywords: | potassium quercetin phosphate thrombin platelet calcium |
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