木芙蓉叶有效组分抗非特异性炎症的实验研究

目的观察木芙蓉叶有效组分(MFR-C)的抗非特异性炎症作用.方法通过大鼠鹿角菜致肿实验、大鼠蛋清致肿实验、小鼠腹腔毛细血管通透性实验和小鼠耳肿胀实验,对木芙蓉叶有效组分抗非特异性炎症的作用进行评定.结果 MFR-C和盐酸青藤碱对鹿角菜及蛋清所致的大鼠足肿胀具有良好的抑制作用,与空白对照组相比差异有显著性(P＜0.05);与空白组相比,MFR-C对乙酸引起的小鼠腹腔毛细血管通透性也具有良好的抑制作用,两者之间差异有显著性意义(P＜0.05);小鼠耳肿胀实验显示MFR-C有抑制二甲苯造成的非特异性耳肿胀作用,与空白组相比P＜0.05,与阳性对照组(盐酸青藤碱)相比有同样的抗炎消肿作用.结论木芙蓉叶有效组分(MFR-C)对鹿角菜、蛋清、乙酸及二甲苯引起的非特异性炎症具有良好的抑制作用.

Experimental study on anti-inflammatory activity of effective fractions of Hibiscus mutabilis L

Objective To assess the anti-inflammatory activity of the effective fractions of hibiscus mu-tabilis L(MFR-C) Methods By Carrageenin inducing inflammation test, Ovi albumen inducing inflammation test,the acetic acid abdominal inducing capillary penetration test and xylene inducing Ear-swelling test, the MFR-C anti-inflammatory effect was investigated. Results The MFR-C and Sinomonine could significantly inhibit tumefaction cause by Carrageenin or Ovi albumen, compared with blank control group. The difference is significant (P<0.05). The MFR-C could inhibit the increase of peritoneal capillary permeability cause by acetic acid in mice. There was significant difference between MFR-C group and blank control group. Ear-swelling test indicated that MFR-C could significantly suppress the swelling of ear of mice cause by xylene. MFR-C and sinomonine was same on inhibition of swelling and inflammation. Compared with the blank control group, the difference is significant ( P < 0.05 ). Conclusion The effective fractions of hibiscus mutabilis L (MFR-C) have satisfactory inhibition for nonspecific inflammation cause by the Carrageenin, Ovi albumen, acetic acid and xylene.