咖啡摄入前后心率变异性的对比研究 |
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引用本文: | 孙旭君,全海英,张宽. 咖啡摄入前后心率变异性的对比研究[J]. 北京生物医学工程, 2017, 36(6): 614-618,654. DOI: 10.3969/j.issn.1002-3208.2017.06.011 |
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作者姓名: | 孙旭君 全海英 张宽 |
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作者单位: | 首都医科大学生物医学工程学院 北京 100069;临床生物力学应用基础研究北京市重点实验室 北京 100069;首都医科大学生物医学工程学院 北京 100069;临床生物力学应用基础研究北京市重点实验室 北京 100069;首都医科大学生物医学工程学院 北京 100069;临床生物力学应用基础研究北京市重点实验室 北京 100069 |
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摘 要: | 目的研究中等剂量咖啡摄入对青年受试者心率变异性的影响,明确咖啡对心脏自主神经活性的作用。方法无咖啡因摄入习惯的16名健康青年受试者(身高167 cm±7.2 cm、体重61.3 kg±6.3kg、年龄24.9岁±2.8岁)参与本项研究,在摄入含6 mg/kg咖啡因的咖啡饮品后,于8:40~10:45应用动态心电图记录仪(Holter)进行咖啡摄入前后心电信号的采集及心率(heart rate,HR)和心率变异性指标的分析。心率变异性指标包括R-R间期标准差(SDNN)、相邻R-R间期差值的均方根值(r MSSD)、相邻的R-R间期之差大于50 ms的心搏数占总心搏数的百分比(PNN50)、标化低频(normalized low frequency power,LFnorm)、标化高频(normalized high frequency power,HFnorm)、低频功率(low frequency,LF)与高频功率(high frequency,HF)的比值(LF/HF)。结果饮用咖啡后,心率、心率变异性指标均发生改变且具有统计学意义,HR、LFnorm和LF/HF分别降低了7.5%、17%和35%。r MSSD、PNN50和HFnorm分别提高了82%、80%和58%。其中HR及LF/HF随着时间的变化趋势最明显。HRV参数在饮用咖啡前后的差值ΔLF与ΔHF,ΔLF与ΔLF/HF均显著相关,相关系数为-0.980和0.903。结论中等剂量咖啡可引起心率变异性的改变和心率的降低,抑制交感神经活性,提高副交感神经活性。
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关 键 词: | 咖啡 咖啡因 动态心电图 心率 心率变异性 |
Effect of coffee on heart rate variability |
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Abstract: | Objective To study the effect of coffee on heart rate variability( HRV) in young adults in order to determine the effect of coffee ingestion on cardiac autonomic nervous system ( ANS ) activity. Methods There were sixteen healthy young nonhabitual caffeine consumers as subjects enrolled in this study( height 167 cm±7. 2 cm,body mass 61. 3 kg±6. 3 kg,age 24. 9 years±2. 8 years). Coffee ingested by the subjects was 6 mg/kg caffeine as moderate dosage. And the dynamic electrocardiogram signals were recorded and analyzed with a dynamic Holter before and after coffee ingestion during 8:40 to 10:45 in the morning. HRV parameters included the mean standard deviation of all NN intervals,the root mean square of successive differences(rMSSD),the percentage of successive NN intervals differing >50 ms ( PNN50 ) , the normalized low frequency power (LFnorm),the normalized high frequency power(HFnorm),and the low frequency(LF)and high frequency ( HF) ratio LF/HF. Results There were significant differences before and after taking coffee in HRV parameters and the mean heart rate ( HR ) . HR, LFnorm, LF/HF decreased 7. 5%, 17% and 35%, respectively. rMSSD, PNN50 and HFnorm increased 82%, 80% and 58%, respectively. HR and LF/HF changed more obviously over time after taking coffee.ΔLF was highly correlated with ΔHF and ΔLF/HF with the correlation coefficients of -0.980 and 0.903. Conclusions Coffee with moderate dosage caffeine can cause the change of HRV and the decrease of HR, inhibit sympathetic nervous system activity(SNSA),and enhance parasympathetic nervous system activity(PNSA). |
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Keywords: | coffee caffeine Holter heart rate heart rate variability |
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