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| 丹玄口康治疗口腔黏膜下纤维化的临床研究 | |
| 引用本文： | 谭劲,李元聪,陈安,彭楚湘,陈明,陈世娟,伍春华. 丹玄口康治疗口腔黏膜下纤维化的临床研究[J]. 湖南中医药大学学报, 2006, 26(5): 41-43 |
| 作者姓名： | 谭劲 李元聪 陈安 彭楚湘 陈明 陈世娟 伍春华 |
| 作者单位： | 1. 湖南中医药大学第一附属医院,湖南,长沙,410007 2. 湖南中医药大学,湖南,长沙,410007 3. 湖南中医药大学2003级研究生班,湖南,长沙,410007 |
| 基金项目： | 国家自然科学基金;湖南省中医药管理局科研项目 |
| 摘 要： | 目的探讨丹玄口康治疗口腔黏膜下纤维化（OSF）的临床疗效机制。方法将确诊为OSF的62例患者随机分为两组，治疗组32例，对照组30例，分别给予丹玄口康（DXKK）和雷公藤多甙（LGTDD）口服，观察两种药物的临床疗效及其时外周血T淋巴细胞亚群、血液流变学的影响。结果DXKK治疗OSF临床疗效明显优于LGTDD（P〈0．01）；T淋巴细胞亚群CD4^＋、CD4^＋/CD8^＋明显降低（P〈0．01或P〈0．05）；全血黏度、血浆黏度、红细胞聚集指数等血液流变学各项指标均有明显改善fP〈0．01或P〈0．05）。结论DXKK治疗OSF安全有效，并能显著改善微循环，调节局部免疫。 |
| 关 键 词： | 丹玄口康 口腔黏膜下纤维化 临床疗效 血液流变学 T淋巴细胞亚群 活血化瘀 益气养阴 |
| 文章编号： | 1000-5633（2006）05-0041-03 |
| 收稿时间： | 2006-06-30 |
| 修稿时间： | 2006-06-30 |
Clinical Research of Danxuan Koukang on Treatment of Oral Submucous Fibrosis |
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| TAN Jin,LI Yuan-cong,CHEN An,PENG Chu-xiang,CHEN Ming,CHEN Shi-juan,WU Chun-hua. Clinical Research of Danxuan Koukang on Treatment of Oral Submucous Fibrosis[J]. Journal of Traditional Chinese Medicine University of Hunan, 2006, 26(5): 41-43 | |
| Authors: | TAN Jin LI Yuan-cong CHEN An PENG Chu-xiang CHEN Ming CHEN Shi-juan WU Chun-hua |
| Affiliation: | First Affiliated Hospital, TCM Univ. of Hunan, Changsha 410007, China |
| Abstract: | Objective To investigate the therapeutic mechanism of Danxuan Koukang(DXKK) on oral submucous fibrosis(OSF).Methods 62 patients with OSF were randomly divided into two groups in which 32 cases in experimental group were treated with DXKK and 30 cases in control group with Leigongteng Duodai(LGTDD) orally.The therapeutic effects,changes of subgroup of T lymphocytes and hemorrheology indexes were observed.Results The curative effect of DXKK was much more than that of LGTDD(P<0.01);CD4+? CD4+/CD8+ of T lymphocytes were significantly decreased(P<0.01 or P<0.05);and each index of hemorrheology was significantly improved(P<0.01 or P<0.05).Conclusions DXKK is effective and safe for the treatment of OSF,which indicates that DXKK can significantly improves microcirculation and regulate local immunity. |
| Keywords: | Danxuan Koukang OSF curative effect hemorrheology subgroup of Tlymphocytes activating blood flow and removing blood stasis supplementing qi and nourishing yin |
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