Development and clinical trial of a novel bioactive bone cement |
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Authors: | John Cy Leong Zhaoyang Li William W. Lu |
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Affiliation: | (1) The Open University of Hong Kong, Hong Kong SAR., China;(2) Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR., China |
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Abstract: | Strontium (Sr) and related compounds have become more attractive in the prevention and treatment of osteoporosis. Previously, we developed a novel bioactive bone cement which is mainly composed of strontium-containing hydroxyapatite (Sr-HA) filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) resin. This bone cement is superior to conventional polymethylmethacrylate (PMMA) bone cement in bioactivity, biocompatibility, and osseointegration. It also has shown sufficient mechanical strength properties for its use in percutaneous vertebroplasty (PVP) and total hip replacement (THR). In this paper, we review the in vitro, in vivo and clinical evidence for the effectiveness of this bioactive bone cement. |
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Keywords: | Strontium osteoporosis bioactive bone cement vertebroplasty total hip replacement |
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