A Double-Blind, Multicenter Immunotherapy Trial in Children, Using a Purified and Standardized Cladosporium herbarum Preparation II. In Vitro Results |
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| Authors: | R. Karlsson B. Agrell S. Dreborg T. Foucard N.-I. M. Kjellman A. Koivikko R. Einarsson |
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| Affiliation: | Allergy and Diagnostics Divison, Pharmacia AB, Uppsala;Dept. of Pediatrics, University Hospital, Uppsala;Dept. of Pediatrics, University Hospital, Linköping, Sweden;Dept. of Pediatrics, University Hospital, Turku, Finland |
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| Abstract: | This double-blind immunotherapy trial in children, using a purified and standardized Cladosporium herbarum allergen preparation, has shown that children with mould asthma and/or rhinoconjunctivitis, responded to immunotherapy with a decrease in specific IgE and a significant increase in specific IgG. There was a marked increase in the ratio specific IgG/specific IgE as a result of active treatment. IgE-CRIE radiostaining patterns showed no pronounced changes after 10 months' active treatment and no "new sensitivities" could be detected in the studied patients. IgG-CRIE radiostaining, primarily directed towards the important allergens, was significantly increased in the active group and particularly towards Ag-12 (partially identical to a previously described major allergen in Cladosporium herbarum, Ag-54). Children treated with histamine placebo showed no change in antibody patterns during 10 months of treatment. |
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| Keywords: | Cladosporium herbarum IgE-CRIE IgG-CRIE RAST IgG-RAST immunotherapy |
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