药物代谢酶CYP2D6基因多态性及表型的研究进展

CYP2D6是人体内细胞色素P450家族中一种重要的药物代谢酶,其催化的药物种类广泛.多年研究表明,编码该酶的基因存在遗传多态性且该多态性与药物代谢、药物不良反应(adverse drug reaction,ADR)的产生和致癌物的活化关系密切.随着人类基因组计划的完成和基因多态性研究计划的开展,近年来对该基因多态性及其与表型关系的研究再次成为遗传药理学研究的热点.本文从CYP2D6基因多态性及其发生机制,多态性对药物代谢、相关疾病易感性的影响等四个方面对此进行综述.

Drug-Metabolizing Enzyme CYP2D6 Polymorphism and Phenotypes

CYP2D6,as a member of cytochrome P450 family,is an important drug-metabolizing enzyme which catalyzes metabolism of a wide variety of drugs.It has been shown for years that the gene coding CYP2D6 enzyme has genetic polymorphism,which shows a close relationship with drug metabolism,adverse drug reaction and activation of carcinogenic substance.With the completion of human genome project and the beginning of gene polymorphism research project,the researches about polymorphism of CYP2D6 gene,and its relationship with clinical phenotypes has become one of important topics in the area of pharmacokineties.We will review CYP2D6 gene polymorphism,its production,and its influences on drug metabolism and susceptibility to certain diseases.