| 番荔枝内酯抗肿瘤作用研究进展 |
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| 引用本文： | 张丹,王晓文,岳秉飞,唐劲天.番荔枝内酯抗肿瘤作用研究进展[J].国际肿瘤学杂志,2009,36(7):649-652. |
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| 作者姓名： | 张丹 王晓文 岳秉飞 唐劲天 |
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| 作者单位： | 北京中医药大学中药学院生物制药系;清华大学工程物理系医学物理与工程研究所,北京,100084; |
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| 摘 要： | 番荔枝内酯(ACG)是一类从多种番荔枝科植物中提取的长碳链脂肪酸内酯,具有广谱抗肿瘤作用.番荔枝内酯来源丰富,具有广阔开发应用前景.动物实验发现,番荔枝内酯毒性较大.目前通过化学修饰或结构改造,提高其抗肿瘤活性、生物利用度并降低毒性,是番荔枝内酯药物的研发方向.
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| 关 键 词： | 内酯类 抗肿瘤药 |
Anti-tumor effects of annonaceous acetogenins |
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| Abstract: | Annonaceous anetogenins(ACG) are a large family of fatty acid-derivednatural products ex-tracted from annonacea with broad spectrum of anticancer activity. ACG are rich in resources and have broad prospects for development and application. In vivo studies show that ACG have great toxicity, which inhibites their applications and drug development. Chemical modification and structure reformation can improve the anti-tumor activity and bioavailability of ACG, which will be the direction for ACG anti-tumor drugs research. |
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| Keywords: | LactonesAntineoplastic agents |
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