先天免疫Toll样受体在哮喘病中作用的研究进展

哮喘病的高发性和普遍性使哮喘病成为人们极度关注的健康问题,哮喘病的特征是呼吸道阻塞和支气管的过度炎性反应.虽然对后大获得性免疫在哮喘病中的作用已进行了广泛地研究,但是先天免疫在哮喘病中的重要件是最近才被发现的.先大免疫不但提供抗感染的第一道防线,而且调控后天获得件免疫的激活.Toll样受体是先大免疫的关键感受器,它也是研究最多的模式识别受体.激活的Toll样受体信号传导通路可以很快引起与炎性反应和免疫反应相关的各种基因的表达.本义综述了了目前天于Toll样受体在哮喘病中作用的研究进展.

The role of innate immune Toll-like receptors in atopic asthma

The high prevalence and incidence of atopic asthma has highlighted this disease as an important health problem to be addressed. This chronic disorder is characterized by airflow obstruction, bronchial hyperresponsiveness, and inflammation. The role of adaptive immunity in atopic asthma has been extensively studied; however the importance of innate immunity in this disease is beginning to be uncovered. Toll-like receptors are pathogen-recognition receptors ( PRRs) that recognize pathogen-associated molecular patterns ( PAMPs). These receptors have been found to be expressed extensively in the airway. Epidemiological and genetic studies have linked TLR2 and TLR4 with atopic disease. Also, in vivo and in vitro studies of T1,K2, TLR4 and TLR9 with their respective ligands have associated these receptors with the activation or decrease of the adaptive response. This review attempts to discuss the most relevant data that links allergic asthma with TLRs.