肝干细胞来源、定向分化及其转化机制 |
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引用本文: | 夏焱,俞继卫,姜波健. 肝干细胞来源、定向分化及其转化机制[J]. 国际外科学杂志, 2009, 36(7): 699-703. DOI: 10.3760/cma.j.issn.1673-4203.2009.10.019 |
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作者姓名: | 夏焱 俞继卫 姜波健 |
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作者单位: | 上海交通大学医学院附属第三人民医院普外科,上海,201900; |
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摘 要: | 本文综述了近年来胚胎、造血、肝内祖细胞和小肝细胞样祖细胞、骨髓、间充质来源干细胞定向向肝细胞分化的研究进展,并阐述了干细胞转化为肝细胞的机制是融合还是转化.对此深入研究可望为肝干细胞移植和基因治疗带来希望,进而为临床肝移植面临的供肝短缺提供可选择的补充治疗方法.
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关 键 词: | 肝 干细胞 分化 |
Diffenent sources,differentiation and transforming mechanism of liver stem cells |
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Abstract: | To review the progresses of embryonic stem cells,hematopoietic stem cells,oval cells and small hepatocyte-like progenitor cell in liver,bone marrow-derived liver stem cells and mesenchymal stem cells as well as the mechanism of them differentiating to hepatocytes. |
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Keywords: | liverstem celldifferentiation |
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