| 青藤碱微乳的相图研究及质量控制 |
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| 引用本文： | 张先洲,祝红达,夏莉,潘细贵. 青藤碱微乳的相图研究及质量控制[J]. 中国医院药学杂志, 2006, 26(10): 1228-1231 |
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| 作者姓名： | 张先洲 祝红达 夏莉 潘细贵 |
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| 作者单位： | 1. 武汉大学人民医院,湖北,武汉,430060
2. 武汉大学药学院,湖北,武汉,430060 |
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| 摘 要： | 目的:研究青藤碱微乳的处方、制备,并建立其含量测定方法。方法:通过滴定法绘制伪三元相图,根据相图优选处方,并初步考察青藤碱微乳的稳定性、粒径分布和理化性质。用HPLC法测定微乳中青藤碱的含量。结果:青藤碱微乳稳定,平均粒径为35.67nm,多分散指数0.237。HPLC线性关系良好,平均回收率为99.33%,RSD为0.91%(n=9)。结论:该处方设计合理,制剂稳定,易于制备。含量测定方法可靠,重复性好。
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| 关 键 词： | 青藤碱 微乳 伪三元相图 高效液相色谱法 |
| 文章编号： | 1001-5213(2006)10-1228-04 |
| 收稿时间： | 2004-04-20 |
| 修稿时间： | 2004-04-20 |
Preparation and phase diagram of sinomenine microemulsion |
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| ZHANG Xian-zhou,ZHU Hong-da,XIA Li,PAN Xi-gui. Preparation and phase diagram of sinomenine microemulsion[J]. Chinese Journal of Hospital Pharmacy, 2006, 26(10): 1228-1231 |
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| Authors: | ZHANG Xian-zhou ZHU Hong-da XIA Li PAN Xi-gui |
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| Affiliation: | 1. The Renmin Hospital of Wuhan University, Hubei Wuhan 430061 |
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| Abstract: | OBJECTIVE To study the optimum formulation and preparation of sinomenine microemulsion,and to establish a method to determine sinomenine.METHODS The optimum formulation was investigated by using titration to prepare the Pseudo-ternary phase diagram,testing the size distribution,stability and physico-chemical property of sinomenine microemulsion; sinomenine was determined by HPLC.RESULTS The stability of sinomenine microemulsion was good,average size was(35.67) nm,polydispersity index was (0.237).the average recovery was(99.33%),with RSD of(0.91%).CONCLUSION The formulation is reasonable,sinomenine microemulsion has good stability,the method for determining sinomenine is accurate and reliable |
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| Keywords: | sinomenine microemulsion pseudo-ternary phase diagram HPLC |
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