一氧化氮与急性白血病中医辨证分型关系的研究

目的 :探讨NO测定在急性白血病中的意义及与不同证型间的关系。方法 :选取 2 0例健康者作为正常对照组 ,39例急性白血病患者作为观察组 ;分别测定观察组在急性发作期及缓解期 (包括完全缓解、部分缓解 )的血清NO含量 ,同时按中医原则进行辨证分型 ,比较不同证型间血清NO含量的变化。结果 :观察组血清NO含量在急性发作期显著增高 ,缓解期降低 ,较正常组仍增高 ,但无统计学差异 ;发作期与缓解期相比 ,差异具有显著性 ;且NO含量在各证型中的次序为 :热毒蕴结型 (A组 )、痰瘀互结型 (B组 ) >湿热内蕴型 (C组 ) >气血两虚型 (D组 )、气阴两虚型 (E组 )。结论 :可将NO含量作为判断急性白血病病情发展的一种监测指标 ,并可作为中医辨证分型的客观指标

Study of relationship between NO and acute leukemia's traditional Chinese medical typing

Objective: It is to probe the significance of nitric oxide (NO) in leukemia and the relationship between NO and acute leukemia's traditional Chinese medical typing. Methods: Twenty healthy persons were chosen as normal control group. Thirty nine patients with acute leukemia were chosen as treatment group. The serum concentration of NO was measured in acute stage and remission stage, which included complete remission stage and partial remission stage. The changes of NO were studied and compared in different types of TCM. Results: The level of NO of treatment group was significantly higher in acute stage than that in remission stage and in normal group. And that in remission stage was lower than that in acute stage, but the difference did not reach the statistical significance. The order of NO level in different typing was both "retention of toxic heat in the interior" and "retention of phlegm blood", "retention of damp heat in the interior", both "deficiency of Qi and blood", and "deficiency of both Qi and Yin". Conclusion: The concentration of NO can contribute to estimate the state of acute leukemia and also be an objective guideline for classifying acute leukemia in traditional Chinese medicine.