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| 糖皮质激素诱导肿瘤细胞抗凋亡的信号转导通路 | |
| 引用本文： | 曹菲,张智慧,黄建鸣,查晓.糖皮质激素诱导肿瘤细胞抗凋亡的信号转导通路[J].医学综述,2008,14(13):2033-2036. |
| 作者姓名： | 曹菲 张智慧 黄建鸣 查晓 |
| 作者单位： | 1. 广西医科大学,南宁,530021 2. 四川省肿瘤医院肿瘤内科,成都,610041 3. 四川省肿瘤研究所,四川,成都,610041 |
| 摘 要： | 糖皮质激素(如地塞米松)对大多数非实体性肿瘤(如淋巴瘤)具有促凋亡和抗增殖的作用而被广泛应用于肿瘤的治疗。另有研究表明,地塞米松联合细胞毒药物治疗实体瘤,可诱导起源于上皮组织的多种恶性肿瘤对化疗药物介导的细胞凋亡产生抵抗而影响疗效。因此,抗肿瘤药物联合糖皮质激素治疗实体肿瘤日渐引起临床工作者的关注。糖皮质激素诱导实体肿瘤细胞抗凋亡的作用与细胞类型有关,其分子机制与功能性糖皮质激素受体介导的细胞信号转导通路相关。现对糖皮质激素诱导肿瘤细胞抗凋亡作用的信号转导通路进行综述。 |
| 关 键 词： | 糖皮质激素 糖皮质激素受体 凋亡 抗凋亡 生存 化疗 |
The Signal Transduction Pathway of Glucocorticoid-induced Anti-apoptosis in Tumor Cells |
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| CAO Fei,ZHANG Zhi-hui,HUANG Jian-ming,ZHA Xiao.The Signal Transduction Pathway of Glucocorticoid-induced Anti-apoptosis in Tumor Cells[J].Medical Recapitulate,2008,14(13):2033-2036. | |
| Authors: | CAO Fei ZHANG Zhi-hui HUANG Jian-ming ZHA Xiao |
| Institution: | CAO Fei1,ZHANG Zhi-hui2,HUANG Jian-ming3,ZHA Xiao3.(1.Guangxi Medical University Guangxi Nanning 530021,China,2.Department of Medical Oncology,Sichuan Provincial Tumor Hospital,Chengdu,Sichuan 610041,3.Sichuan provincial Tumor Institute,China) |
| Abstract: | Glucocorticoids (GCs) such as dexamethasone (DEX) have been used in tumor therapy widely because of its effect of promoting apoptosis and anti-proliferation on most of non-solid tumor ( such as lymphoma).However,studies have shown that dexamethasone combining with the cytotoxicity during tumor therapy can induce resistance to apoptosis reduced by chemotherapeutics in many malignant tumor derived from epithelial tissue.Therefore,the co-medication of antitumor drugs and glucocorticoids in cancer therapy for s... |
| Keywords: | Glucocorticoids Glucocorticoids receptor Apoptosis Anti-apoptosis Survival Chemotherapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |