9 9mTC-紫杉醇脂质体的抑瘤作用及体内分布研究

观察＾９９ｍＴＣ紫杉醇脂质体瘤作用及其体内分布，为临床应用提供依据。方法：采用逆相蒸发法制备紫杉醇脂质体，小鼠艾氏癌实体型为实验肿瘤模型。经腹腔分别注入生理盐水，紫杉醇注射液和紫杉醇质体，观察抑瘤率和体重变化率；经尾静脉分别注入＾９９ｍＴｃ紫杉醇脂质体和＾９９ｍＴｃＯ４－洗脱液观察体内分布情况。结果紫杉醇脂质体与紫杉醇注且抑瘤率差异无显著性；同生理盐水相比，紫杉醇脂质体组的体重变化率无统计学意义，

Studies of 99mTc-paclitaxel-liposome:antitumor effect and biodistribution

Purpose:To observe the antitumor activity and biodistribution of 99m Tc paclitaxel liposome.Methods:Paclitaxel liposome was prepared by reverse phase evaporation method. Ehrlich tumor xenografts in mice were established for studies.The weight changes of the mice and tumors weight,after injection of saline,paclitaxel, paclitaxel liposome via i.p.,were analyzed. 99m Tc labeled paclitaxel liposome and 99m TcO - 4 solution was injected through tail vein into the mice.Biodistribution was investigated under SPECT after 2hr,and the uptake rates of tumor,liver,spleen and lung were calculated.Results:The difference in antitumoractivity between the free and liposomal paclitaxel was not statistically significant,but weight changes were statistically significant.A high uptake was found in the liver and spleen.Conclusion:Free and liposomal paclitaxel showed similar antitumor effect,but the toxicity of paclitaxel liposome was lower.The accumulation of radioactive paclitexel was mainly in liver and spleen without targeting on tamor mass.