视觉诱发电位在糖尿病视网膜病变诊断中的应用

目的:探讨图形视觉诱发电位(P-VEP)与糖尿病视网膜病变(diabetic retinopathy,DR)的关系。方法:对正常对照者及糖尿病患者分别测P-VEP潜伏期LN75、LP100、LN145及波幅AN75、AP100、AN145。结果:糖尿病患者视网膜尚未出现病变时,P-VEP的潜伏期已明显延迟,随着糖尿病视网膜病变程度的进一步发展,P-VEP潜伏期进一步延迟,但未达显著性差异。DR及各期波幅下降不显著。P-VEP的潜伏期及波幅与视力无关,糖尿病病程早期潜伏期已明显延长,P-VEP波幅与病程无关。结论:糖尿病早期P-VEP潜伏期即有明显延长,P-VEP潜伏期比波幅具更好的临床使用价值。

Pattern of visual evoked potential in the diagnosis of diabetic retinopathy

·AIM:To observe the changs of pattern visual evoked potential(P-VEP)in patients with diabetic retinopathy(DR),and to explore the relations between P-VEP and DR..METHODS:The P-VEP was examined in normal indivi-duals and patients with diabetes mellitus(DM).The latency of N75,P100,N145 and the amplitude of N75,P100,N145 were measured..RESULTS:Even in DM patients without DR,the P-VEP latency of N75,P100,N145 was significantly delayed(P<0.05),but its amplitude was not significantly reduced in the DM group.Visions of DM patients were not related to the change of latency and amplitude of the P-VEP.In the early stage of DM,the P-VEP latency of N75,P100,N145 was significantly delayed(P<0.05),and its amplitude was not related to the course of DM..CONCLUSION:In the early stage of diabeteds mellitus,the latency of P-VEP was significantly delayed The latency of P-VEP can possibly reflect the damage degree of DR more preferably than its amplitude..