分化型甲状腺癌的多因素预后分析

 【目的】探讨影响分化型甲状腺癌（differentiated thyroid carcinoma，DTC）预后的因素。【方法】回顾性收集1985年1月1日至1997年12月31日在中山大学肿瘤防治中心治疗的分化型甲状腺癌581例，对其预后进行单因素和多因素分析。【结果】581例分化型甲状腺癌的5、10、15年生存率分别为93．6％、87．5％和80．6％。单因素分析显示影响分化型甲状腺癌预后的因素有性别、年龄、肿瘤大小、T分期、远处转移、治疗方式、复发和临床病理分期，P〈0．05，病理类型、淋巴结转移对预后无显著性影响，P〉0．05。Cox多因素分析表明T分期、治疗方式和临床病理分期是影响分化型甲状腺癌预后的独立因素。【结论】性别、年龄、肿瘤大小、T分期、复发、远处转移和临床病理分期是影响分化型甲状腺癌预后的主要因素，其中T分期、治疗方式和临床病理分期为独立的预后因素。

Multivariate Prognosis Analysis of Differentiated Thyroid Carcinoma

[Objective] To investigate the factors that influence the prognosis of differentiated thyroid carcinoma(DTC).[Methods] A total of 581 cases of DTC treated at Cancer Center,SUN Yat-Sen University from January 1st,1985 to December 31st,1997 were collected retrospectively,univariate and multivariate analyses were applied to analyze the prognosis of DTC.[Results] The overall 5-year,10-year,and 15-year survival rates of 581 cases of DTC were 93.6%,87.5%,and 80.6%,respectively.In univariate analysis,the factors that influenced the prognosis of DTC included gender,age,primary tumor size,T stage,distant metastasis,treatment pattern,recurrence and clinicopathological stage(P< 0.05),and the pathological type,lymph node metastasis had not significant influence on prognosis(P >0.05).T stage,treatment pattern and clinicopathological stage were independent factors which influenced the prognosis of DTC according to Cox multivariate analysis.[Conclusion] Gender,age,primary tumor size,T stage,recurrence,distant metastasis and clinicopathological stage were main factors that influenced the prognosis of DTC and T stage,treatment pattern and clinicopathological stage were independent prognostic factors among them.